In 1885 Abigail Wilson joined an archaeological dig at the Colosseum in Rome. Now, 15 years later, she is famed as a renowned 'digger' and one half of the Museum Detectives alongside her husband Daniel. Abigail has been invited to be a speaker at a Conference on Ancient Roman Civilization, held in Rome.

Daniel and Abigail decide to use this conference to extend it to a holiday in the Eternal City, but when a fellow archaeologist and his wife are found shot dead in the Colosseum, the Wilsons find themselves at the heart of the murder investigation.